Theme: LOST IN SPACE (57A: TV sci-fi series, first aired 9/15/1965, on which a robot spoke the catchphrase formed by the first words of 17-, 26-, and 42-Across).
17A: Toon rodent who's a British secret agent: DANGER MOUSE.
26A: Suitor's proposal: WILL YOU MARRY ME?
42A: Shipwrecked literary hero: ROBINSON CRUSOE.
Melissa Bee blogging.
DANGER, WILL ROBINSON! Even though I never watched LOST IN SPACE, I got the answer immediately. Wikipedia says the phrase was only used once on the show.
Fairly straightforward puzzle, with a few unknowns to make it interesting. Three letters short of a pangram (J, Q and X).
Donna S. Levin has a knack for tribute puzzles. We just had her "The Wizard of Oz" (70-year anniversary) last month.
Across:
1A: Actress Messing of "Will & Grace": DEBRA.
6A: Nothing, in Latin: NIHIL. “Nihil aude, nihil obtine." Risk nothing, gain nothing.
11A: 6-Across suffix: ISM. Who said, "ism's, in my opinion, are not good."?
15A: Endangered layer: OZONE.
21A: "Look Homeward, Angel" author Thomas: WOLFE. His autobiographical first novel. One of my unknowns. Easy to confuse him with "The Bonfire of Vanities" author Tom WOLFE.
32A: Baseball's "Big Unit" _____ Johnson: RANDY. 6' 10" Pitcher for SF Giants. "Big Unit" indeed. Left-handed. Second All-time in strikeouts (4,867), after Nolan Ryan. Don't confuse him with Baseball's "The Big Train" Johnson, Hall-of-Famer Walter Johnson (right-handed).
33A: Cattle drive buddy: PARD. If you insist. And 62A: Buddy: PAL.
36A: Bouquet: SCENT. I tried to 'smell' it first.
38A: Litter weakling: RUNT.
40A: German name for Cologne: KOLN. I must have been absent the day we learned that.
46A: "_____ directed": medication warning: USE AS.
47A: Ship, to a sailor: HER.
50A: Mike Nichols's comedy partner: ELAINE MAY. Improvisational comedy duo from the 1960's. No idea.
59A: Nipper's co.: RCA. The famous dog listening for his master's voice.
64A: Two foursomes: OCTET. Sometimes it's OCTAD.
64A: Two foursomes: OCTET. Sometimes it's OCTAD.
Down:
1D: Bombs that don't go off: DUDS.
2D: Actor Morales: ESAI. Crossword staple.
3D: 1930s-'40s German-American political group: BUND (boond). Wikipedia says 'Its main goal was to promote a favorable view of Nazi Germany.'
6D: "Hold the Hellmann's": NO MAYO. I've never uttered those words in my life.
7D: Shirt that once had a reptilian logo: IZOD.
8D: Male Servant: HOUSEMAN. You're hired.
9D: Aetna's business: Abbr: INS. Aetna is named after Mt Etna, the Sicilian volcano.
10D: Moving toward the calmer side, at sea: LEEWARD. Opposite of windward. See?
11D: "Shoulda listened to me!": I TOLD YOU SO. Or, as my aunt used to say, 'I mentioned that.'
18D: Actor Calhoun: RORY.
22D: Hockey legend Bobby: ORR. Bruins #4. RANDY Johnson always wears #51, except when he was with the Yankees.
25D: Golfer's wheels: CART.
26D: Loony one: WACKO. Irritating word.
27D: How a debater's response is made: IN REBUTTAL. There you go again.
28D: Mormon's gp.: LDS. Latter-Day Saints.
29D: Philly Ivy League sch.: U PENN.
30D: Minister's home: MANSE.
31D: Art Deco designer: ERTE. A gimme, thanks to C.C.
32D: Trailer park resident, for short: RV'ER. Recreational Vehicle. Not so much. I don't normally think of a trailer park and an RV park as the same thing.
36D: Slugger Sammy: SOSA. Sometimes it's "Slamming Sammy", which could also refer to the legendary golfer Sam SNEAD.
37D: Forms an increasingly smaller circle around, with "on": CLOSES IN. Another long clue.
38D: Coll. dorm VIPs: RA'S. Resident Assistants.
40D: Prepared to say 26-Across: Kneeled. Aw. Two cross-references in today's grid.
41D: Seeks help from: TURNS TO.
43D: Cuba or Aruba: Abbr: ISL. Island. Nice rhyme.
44D: Common poolside chair: CHAISE.
45D: Bridle part: REIN. Argyle has educated us about this before.
48D: Ball field protector: TARP.
49D: Peruvian of old: INCA.
51D: Former Ford cars: LTDS.
53D: Enhanced milkshake: MALT 54D: Entr' ____: intermission: ACTE. French for 'between the acts.'
55D: Mon., on Tues.: YEST (Yesterday). Today is Tuesday. Rich is quite attentive to this detail.
58D: Four quarters: ONE. Four quarters make one whole. "12D starter?" would be a great cross-reference clue too.