Theme: Not all of it - The first word can follow SAVE.
50D. "That's enough!" ... or what one can do with the first word of 17-, 27-, 45- and 60-Across : "SAVE IT!"
17. "Back to the Future" subject : TIME TRAVEL. Save time, a good idea.
27. "Cash makes things happen" : MONEY TALKS. Save time and money, even better idea.
45. Cosmetic applied after foundation : FACE POWDER. Save face, avoid embarrassment and keep respect.
60. Ditzy one : SPACE CADET. Save space, leave room for future stuff.
Argyle here, saving space for C.C. She adds so much to the world of cruciverbalism.
Across:
1. Use an S.O.S pad : SCRUB
6. Skidded : SLID
10. "Better Call __": "Breaking Bad" spin-off : SAUL
14. Circus venue : ARENA
15. Kiss : BUSS
16. "One more thing ... " : "ALSO ..."
19. Partners of hems : HAWs. Hems and haws. Gees and haws are horse talk.
20. "Who __ to argue?" : AM I
21. Steed : HORSE
22. Impressionist Édouard : MANET
23. "Anything you say, honey" : "YES, DEAR"
25. Saintly glows : AURAE
26. Fed. assistance program : SSI. (Supplemental Security Income)
31. Tie settlers: Abbr. : OTs. (overtime)
33. Disable a surveillance camera for, say : ABET. New clue.
34. Ovid's 551 : DLI
35. Prefix with state or coastal : INTRA
38. UN delegate : AMB. (ambassador)
39. Signs off on : OKAYs
41. "Give __ break" : ME A. "Better call Saul"
42. "Dirty Jobs" host Mike : ROWE. Dirty Jobs is a TV series on the Discovery Channel.
44. "State of the Union" channel : CNN. (Cable News Network)
48. RN workplaces : ORs. (operating room)
51. Antidote target : TOXIN
52. "Piece of cake" : "NO SWEAT"
55. Dalai Lama's land : TIBET
56. African country whose capital is Accra : GHANA
58. Ill. and Ind., in Monopoly : AVE.
59. Genesis progenitor : ADAM
62. Cop's quarry : PERP and 2D. They're committed by 62-Acrosses : CRIMES
63. History : PAST
64. Holmes of "Batman Begins" : KATIE. Katie Holmes portrays Rachel Dawes, a childhood friend of Bruce Wayne's.
65. NCAA's Big __ Conference : EAST
66. Egyptian snakes : ASPs
67. They may be called or fired : SHOTS. If you call the shots then pot shots may be fired at you.
Down:
1. Skewered Asian snack : SATAY. Check out the different types. Wiki
3. Negligent : REMISS
4. One at the Louvre : UNE
5. Get into hot water : BATHE
6. Chain known for its New York pizza : SBARRO
7. Huggies rival : LUVS
8. "It's clear now" : "I SEE"
9. ISP connection option : DSL. (Digital Subscriber Line)
10. About 30% of Africa : SAHARA
11. Hawkeye Pierce portrayer : ALAN ALDA
12. People shelfmate : US WEEKLY
13. Suffered defeat : LOST
18. Wanders : ROAMS
22. Adult sheep meat : MUTTON
24. Christian of fashion : DIOR
25. Thumbs-up vote : AYE
28. Dubbed : NAMED
29. Tidal decline : EBB
30. Nickname for a sib : SIS
32. La Brea attraction : TAR PIT
35. Worldwide lending org. : IMF. (International Monetary Fund)
36. "Great suggestion" : "NEAT IDEA"
37. Folded fare facilities : TACO BARS. Such alliteration.
38. "Isn't that cute?" : "AWW!"
40. Not just assume : KNOW
43. Suffix with ball : OON. (balloon)
44. Hag : CRONE
46. Not subject to taxes : EXEMPT
47. Passes, as a law : ENACTS
49. Enjoy a bedtime ritual with : READ TO
53. Pile in Santa's sleigh : SACKS. Santa only needs one sack.
54. Dijon heads : TÊTEs
55. Wrapping aid : TAPE
56. Transcript stats : GPAs. (grade point average)
57. Diary clasp : HASP
60. Après-ski option : SPA
61. 60-Down reaction : [AAH!]
Argyle